Meeting Schedule
Sunday, 5 October
9:30-13:30
Registration
10:30-12:30
Sightseeing (for participants arriving early)
13:00-14:00
Lunch
14:00
Welcome and introduction: Barbara van Loon (Norwegian University of Science and Technology, NO) and Bevin P. Engelward (Massachusetts Institute of Technology, USA)
14:10-15:10
Keynote Address
14:10-14:20
Introduction – Vilhelm Bohr
14:20-15:10
Chuan He (University of Chicago, USA), Reexamine UV damage repair
15:10-15:40
Coffee break
15:40-18:30
Physiological consequences of endogenous DNA damage
15:40-15:50
Discussion leader: Barbara van Loon
15:50-16:15
Joann Sweasy (University of Nebraska Medical Centre, USA), Genetic Variants in DNA Repair and Human Disease
16:15-16:30
Talk selected from abstracts
16:30-16:55
Peter J. McKinnon (St. Jude Children’s Hospital, USA), The impact of endogenous topoisomerase DNA damage
16:55-17:10
Talk selected from abstracts
17:10-17:25
Break
17:25-17:50
Deborah Caswell (Francis Crick Institute, UK), The role of APOBEC3B in lung adenocarcinoma tumor progression and targeted therapy resistance
17:50-18:05
Talk selected from abstracts
18:05-18:30
Keith Caldecott (University of Sussex, UK), ADP-ribosylation in DNA strand break repair and DNA replication
19:00-19:30
Refreshments
20:00
Dinner
Monday, 6 October
9:00-12:15
Endogenous DNA damage in accelerated ageing
9:00-9:10
Discussion leader: David M. Wilson III
9:10-9:35
Patricia L. Opresko (University of Pittsburgh, USA), Oxidative DNA damage and repair at telomeres
9:35-09:50
Talk selected from abstracts
9:50-10:05
Talk selected from abstracts
10:05-10:45
Coffee break
10:45-11:10
Björn Schumacher (University of Cologne, DE), Genome Stability in Aging and Disease: New Insights from C. elegans
11:10-11:35
Sofie Lautrup (University of Oslo, NO), Restoring the NAD+-mitophagy axis delays accelerated ageing in Werner syndrome and beyond
11:35-11:50
Talk selected from abstracts
11:50-12:15
Martijn Luijsterburg (Leiden University Medical Center, NL), Molecular mechanisms in transcription-coupled DNA repair
13:00-14:00
Lunch
14:00-17:05
Coordination of DNA repair
14:00-14:10
Discussion leader: Magnar Bjørås
14:10-14:35
Amy Whitaker (Fox Chase Cancer Center, USA), Regulation of cancer-associated genes via DNA damage and repair
14:35-14:50
Talk selected from abstracts
14:50-15:15
Anna Campalans (François Jacob Institute of Biology, FR), Repair of oxidative DNA damage in the chromatin context
15:15-15:45
Coffee break
15:45-16:10
Sheila S. David (University of California, Davis, USA), Mysteries of MUTYH glycosylase: Mechanism, metal cofactors and MAP
16:10-16:25
Talk selected from abstracts
16:25-16:50
Primo Schär (University of Basel, CH), TBA
16:50-17:05
Talk selected from abstracts
17:05-17:40
Poster pitches – Session 1
17:45-19:15
Poster session 1 & refreshments
20:00
Dinner
Tuesday, 7 October
8:30-11:20
Enabling Technologies
8:30-8:40
Discussion leader: Bevin P. Engelward
8:40-9:05
Alberto Ciccia (Columbia University, USA), CRISPR-based approaches to study the DNA damage response
9:05-9:20
Talk selected from abstracts
9:20-9:45
Zachary D. Nagel (Harvard T.H. Chan School of Public Health, USA), Functional assays reveal new players in the repeat instability game
9:45-10:15
Coffee break
10:15-10:40
Cathrine B. Vågbø (Norwegian University of Science and Technology, NO), DNA and RNA modification analysis – how and why
10:40-10:55
Talk selected from abstracts
10:55-11:20
Shana Sturla (ETH, CH), How Damage and Repair Shape Genome-wide Landscapes of Mutations in Cancer
11:30-12:30
Lunch
12:45-14:45
Group activity
14:45-15:00
Coffee and refreshments
15:00-17:50
Crosstalk between Endogenous DNA Damage and RNA Regulation
15:00-15:10
Discussion leader: Hilde L. Nilsen
15:10-15:35
Karlene Cimprich (Stanford University School of Medicine, USA), The Causes and Consequences of Replication Stress
15:35-15:50
Talk selected from abstracts
15:50-16:15
Gianluca Tell (University of Udine, IT), Emerging roles of bases modifications and DNA repair proteins in onco-miR processing: novel insights in cancer biology
16:15-16:30
Break
16:30-16:55
Arne Klungland (Oslo University Hospital, NO), Epitranscriptomic regulation and genome stability in meiosis
16:55-17:10
Talk selected from abstracts
17:10-17:35
Nima Mosammaparast (Washington University, USA), RNA Damage: The canary in the coal mine?
17:50-18:30
Poster pitches – Session 2
18:30-20:00
Poster session 2 & refreshments
20:00
Dinner
Wednesday, 8 October
9:00-12:15
Clinical Potential of Endogenous DNA Damage Targeting
9:00-9:10
Discussion leader: Robert W. Sobol
9:10-9:35
Daniel Durocher (University of Toronto, CA), Synthetic lethality as a tool to uncover sources of endogenous DNA damage
9:35-9:50
Talk selected from abstracts
9:50-10:05
Talk selected from abstracts
10:05-10:45
Coffee break
10:45-11:10
Mark Kelley (Indiana University School of Medicine, USA), Targeting the DNA BER APE1/Ref-1 for cancer and other disease treatments
11:10-11:35
Marit Otterlei (Norwegian University of Science and Technology, NO), Novel roles of PCNA in cellular stress regulation
11:35-11:50
Talk selected from abstracts
11:50-12:15
Mike Yaffe (Massachusetts Institute of Technology, USA), A Multi-Pathway DNA Repair Reporter Reveals Competition, Compensation, and Unexpected Complexity at Single Genomic Double Strand Breaks
13:00-14:00
Lunch
14:30-18:10
At the Intersection of DNA Repair Pathways
14:00-14:10
Discussion leader: Orlando D. Schärer
14:10-15:00
Keynote address: Susan Gasser (Foundation ISREC, CH), Chromatin remodeling in DNA repair: too much, too little, just right
15:00-15:30
Coffee break
15:30-15:55
Ben van Houten (University of Pittsburgh, USA), Watching base excision repair one molecule at a time: seeing is believing
15:55-16:10
Talk selected from abstracts
16:10-16:35
Bruce Demple (Stony Brook University, USA), The Long and the Short of Base Excision Repair in Human Cells and Xenopus Extracts
16:35-16:50
Break
16:50-17:15
Agnel Sfeir (Sloan Kettering Institute, USA), Two Genomes, One Balance: Mitochondrial and Nuclear DNA Stability
17:15-17:30
Talk selected from abstracts
17:30-17:55
Puck Knipscheer (Hubrecht Institute, NL), Repair mechanism of aldehyde-induced DNA interstrand crosslinks
17:55-18:10
Talk selected from abstracts
18:10-18:30
Concluding remarks & poster awards
19:30
Gala dinner
Thursday, 9 October
Breakfast on your own & departure